Hematogenous metastasis of Yoshida ascites Hepatoma in the chick embryo liver: ultrastructural changes in tumor cells.

Establishment of metastatic growth by Yoshida Ascites

Establishment of metastatic growth by Yoshida Ascites Hepatoma 7974 in the chick embryo liver has been studied with light and electron microscopy. Tumor cells lie as emboli within the sinusoids for the first 24 hr and then begin to divide and invade the parenchyma by 48 hr after inoculation. At this time, tumor cells are seen to extend pseudopodia beneath the endothelium, which in many instance...

Some ultrastructural features of Yoshida ascites hepatoma.

Assessment of Biochemical and Histopathological Changes in the Liver of Chick Embryo Treated with a Commercial Deltamethrin Formulation

We studied the hepatotoxic effects of a deltamethrin containing formulation (Decis®) on developing em-bryo of Gallus domesticus. Fertilized eggs were immersed in three different concentrations of deltamethrin (12.5, 25 and 50 mg/L) for 60 min at 37 ˚C prior to incubation (ED 0) and on the 4th day of incubation (ED 4) and incubated till embryonic day (ED) 16. Exposure to 50 mg/L of deltamethrin ...

Metabolic-independent volume changes and Mg++ binding in mitochondria isolated from AH-130 Yoshida ascites hepatoma.

The mitochondria isolated in isotonic sucrose from AH-130 Yoshida ascites hepatoma appear spontaneously swollen (11, 12). This spontaneous swelling may be in part responsible for the inability of tumor mitochondria to undergo extensive volume changes in hypotonie conditions or in conditions that induce large-amplitude, metabolic-dependent, or metabolic-independent swelling in normal liver mitoc...

Inhibition of experimental blood-borne lung metastasis by protease inhibitors.

The inhibitory effects of protease inhibitors on blood-borne metastasis in male Donryu rat lung were studied. Injection i.v. of 10(6) Yoshida ascites hepatoma AH7974 cells induced about 118 +/- 92 (S.D.) metastatic foci in rat lung after 3 weeks. Leupeptin (50 mg/kg body weight twice a day), injected i.p. from 2 days before to 4 days after the inoculation of tumor cells, reduced the number of m...